Abstract of published research articles in Ayurveda
AYU Vol. 30 Issue No. 2 (April-June 2009)
Id.No.30201
Leaky Gut
Syndrome, Dysbiosis, Ama, Free Radicals, and Natural
Antioxidants
* Hari Sharma
Center for Integrative Medicine, The Ohio
State University, Columbus, Ohio, USA.
Abstract:
The
functioning of the gastrointestinal (G.I.) system has
wide-ranging influences on the body that go far beyond the G.I.
tract. According to Ayurveda-the ancient natural health care
system of India - proper diet and digestion are one of the major
pillars of health. Altered digestive functioning can lead to the
production of Ama, a toxic material that initiates and promotes
disease processes throughout the body. Optimal functioning of
the G.I. tract requires proper mucosal integrity and a balanced
microflora. Compromised mucosal integrity which leads to ‘leaky
gut syndrome,’ and imbalances in the microflora known as ‘dysbiosis,’
result in the formation of Ama. Ama is also produced at other
levels of the physiology, including the cellular level.
Excessive formation of free radicals contributes to the
formation of Ama. A variety of free radicals and reactive oxygen
species (ROS) are produced during cellular metabolism. Excessive
amounts of these reactive molecules can cause damage, starting
the disease process. They are believed to be causative agents in
nearly every disease. The ability to control their
concentrations may be helpful for the prevention and treatment
of many disorders. Antioxidants ‘scavenge’ free radicals and
ROS, and render them harmless. Antioxidants can be lipid- or
water-soluble; some are produced in the body and others are
obtained from food or dietary supplements. Natural antioxidants
range from vitamins to enzymes to herbal mixtures. Powerful
antioxidants are present in the bioflavonoids found in
concentrated form in Ayurvedic herbal mixtures known as
Rasayanas. The use of these Rasayanas will be helpful in
neutralizing the excessive free radical activity that
contributes to Ama formation. However, the accumulated Ama in
the body will not be removed by the use of Rasayanas and
antioxidants alone. Other Ayurvedic methodologies are required
to eradicate accumulated Ama. Rasayanas are best utilized to
neutralize ongoing damage to the physiology and regenerate the
system.
