Gujarat Ayurved University

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Abstract of published research articles in Ayurveda AYU Vol. 30 Issue No. 4 (Oct-Dec 2009)



Id.No.30405

Psycho-Neuro-Pharmacological Evaluation of Kushmandadi Ghrita

* Yogita Ahir Ila Tanna * V.J. Shukla B. Ravishankar *H.M. Chandola
Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar

Abstract: This research is carried out with the aim to study psycho-neuro-pharmacological evaluation of Kushmandadi ghrita which comprises Kushmanda (Benincasa hispida), Yashtimadhu (Glycyrrhiza glabra) processed in cow’s ghee. Among them Kushmanda has been repeatedly mentioned as ‘Medhya’ and appreciated for its ‘Chetasovikaranashanam’ effect; Yashtimadhu is included among the four main Medhya Rasayana drugs and also used as routine remedy in the management of the mental illness. Cow’s ghee is considered specially nutritive and increased intellectual faculties. Considering these properties, Kushmandadi ghrita was studied on various experimental models such as Gross behavior, Hypnotic potentiation, Anti convulsant activity, Anti psychotic activity, Anti depressant activity, Chronic fatigue syndrome, Anxiolytic activity & Nootropic activity on Charles Foster strain albino rats and Swiss albino mice. The trial drug showed complex pattern of CNS activity, anti-depressant, anti-anxiety and memory and learning enhancement activities. It also produced good effect on chronic fatigue syndrome. It is devoid of anti-convulsant, central muscle relaxant and anti-psychotic activities.

Key words: Kushmandadi ghrita, anxiolytic effect, anti depressant effect, chronic fatigue syndrome

* Ayurveda Consultant & Counsellor, Atharva Ayu Care, Surat. Email : dr_yogita_ahir@yahoo.com M.D. (Ayu) Scholar, Speciality : Roga Nidan Vikriti Vijnana, I.P.G.T. & R.A. * Head -Pharmaceutical Chemistry Lab. ** Head-Pharmacology Lab. ***Professor of Kayachikitsa & Dean-I.P.G.T. & R.A.




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